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Nuclear damage in <i>LMNA</i> mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope

2021-10-30

Abstract excerpt

The LMNA gene encodes the nuclear envelope proteins Lamins A and C, which comprise a major part of the nuclear lamina, provide mechanical support to the nucleus, and participate in diverse intracellular signaling. LMNA mutations give rise to a collection of diseases called laminopathies, including dilated cardiomyopathy ( LMNA -DCM) and muscular dystrophies. Although nuclear deformities are a hallmark of LMNA...

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Literature Corpus work
9229c3d8-0d33-5019-aadb-b5b691b427db
DOI
10.1101/2021.10.30.466591
Open publication

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