Article

A Novel Hydrogen Polysulfide Donor Alleviates Neuropathic Pain by Enhancing A-Type Potassium Currents via LIMK1-Cofilin Mediated Interaction between Filamin A and Kv4.2

2026-05-28

Abstract excerpt

Hydrogen persulfide (H 2 S 2 ) is an important endogenous signaling molecule, holding significant therapeutic potential across diverse disease models due to its potent antioxidant and redox-regulating properties. Herein, we report the synthesis, characterization, and in vivo evaluation of an esterase responsive H 2 S 2 donor, HPD1 . It reduced mechanical and cold allodynia at 14 mg/kg (i.p.) in chronic constr...

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Literature Corpus work: 958540bd-afc6-5a69-bcc0-bceb59f6bc95
DOI: 10.64898/2026.05.25.727751

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A Novel Hydrogen Polysulfide Donor Alleviates Neuropathic Pain by Enhancing A-Type Potassium Currents via LIMK1-Cofilin Mediated Interaction between Filamin A and Kv4.2DOI 10.64898/2026.05.25.727751Read

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