Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

State-dependent and site-directed photodynamic transformation of HCN2 channel by singlet oxygen.

The Journal of general physiology - 1 May 2014

Gao Weihua, Su Zhuocheng, Liu Qinglian, Zhou Lei

Abstract excerpt

Singlet oxygen ((1)O2), which is generated through metabolic reactions and oxidizes numerous biological molecules, has been a useful tool in basic research and clinical practice. However, its role as a signaling factor, as well as a mechanistic understanding of the oxidation process, remains poor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Amino Acid Sequence
Share to Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Potassium Channels

Share to Protein Structure, Tertiary

Share to Singlet Oxygen

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 24733837
DOI: 10.1085/jgp.201311112
PMCID: PMC4003188

Genes

HCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24733837-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

State-dependent and site-directed photodynamic transformation of HCN2 channel by singlet oxygen.PMID 24733837Read ↗

Photo-crosslinking hERG channels causes a U.V.-driven, state-dependent disruption of kinetics and voltage dependence of activationSemantic proximity Read ↗

Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamicsSemantic proximity Read ↗

Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels.Semantic proximity Read ↗

Structure-guided engineering of a fast genetically encoded sensor for real-time H <sub>2</sub> O <sub>2</sub> monitoringSemantic proximity Read ↗

Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species.Semantic proximity Read ↗

The Multifaceted Roles of Singlet Oxygen: From Fundamental Mechanisms to Groundbreaking Advances in Photodynamic TherapySemantic proximity Read ↗

Oxygen-confined photooxidation represents a novel form of oxidative protein damageSemantic proximity Read ↗

Modulating Protein Function through Genetically Encoded Oxidative ChemistrySemantic proximity Read ↗

Hidden route of protein damage through confined oxygen gasSemantic proximity Read ↗

C-terminal dimerization activates the nociceptive transduction channel transient receptor potential vanilloid 1.Semantic proximity Read ↗

Thiol dependent intramolecular locking of Orai1 channels.Semantic proximity Read ↗

A Second Photoactivatable State of the Anion-conducting channelrhodopsin GtACR1 empowers persistent activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.