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Article

Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase.

Cell chemical biology - 21 Jul 2016

Truong Thu H, Ung Peter Man-Un, Palde Prakash B, Paulsen Candice E, Schlessinger Avner, Carroll Kate S

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a target of signal-derived H2O2, and oxidation of active-site cysteine 797 to sulfenic acid enhances kinase activity. Although a major class of covalent drugs targets C797, nothing is known about its catalytic importance or how S-sulfenylation leads to activation. Here, we report the first detailed functional analysis of C797. In contrast to prior assumptions, mutation...

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Identifiers

PMID: 27427230
DOI: 10.1016/j.chembiol.2016.05.017
PMCID: PMC4958504

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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