Back to search

Article

Engineering an Anaerobic Microenvironment to Empower Hydrogenase-Catalyzed Hydrogen Therapy for Diabetic Wound Healing

2025-12-01

Abstract excerpt

The inherent oxygen sensitivity of hydrogenases has long restricted their applications to anaerobic systems. Here, we present a hybrid peptide–nanocluster hydrogel that establishes a self-sustaining anaerobic microenvironment to enable hydrogenase-catalyzed hydrogen therapy under aerobic conditions. This system integrates a custom-designed Fmoc-KYF peptide hydrogel with integrated silver nanoclusters (AgNCs), whic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e35c5c1e-ca03-58e5-bf8a-9a567260c64e
DOI
10.1101/2025.12.01.691506
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Engineering an Anaerobic Microenvironment to Empower Hydrogenase-Catalyzed Hydrogen Therapy for Diabetic Wound HealingDOI 10.1101/2025.12.01.691506
Multifunctional Hydrogel with Mild Photothermal Properties Enhances Diabetic Wound Repair by Targeting MRSA Energy MetabolismSemantic proximity
Mutant superoxide dismutase 1-catalyzed hydrogen therapy for amyotrophic lateral sclerosis achieved by intercepting oxidative stress-neuroinflammation crosstalk.Semantic proximity
Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamicsSemantic proximity
Structure-guided engineering of a fast genetically encoded sensor for real-time H <sub>2</sub> O <sub>2</sub> monitoringSemantic proximity
Spin-State Modulation by Atom–Cluster Synergy Steers H2O2 Conversion toward a Catalase-like Decomposition Pathway for Anti-Inflammatory TherapySemantic proximity
Efficient active hydrogen delivery for drug-free radiation enteritis therapySemantic proximity
Tetrazine-Enhanced Donor-Acceptor-Donor Photosensitive Metal-Organic Frameworks for Combating Drug-Resistant Bacteria and Accelerating Diabetic Wound HealingSemantic proximity
Unlocking Catalytic Activity via Tuning Fe 3d Spin State in Fe Dual-Atom Nanozymes with Atomically Dispersed Fe2-N6 Configurations for Reprogramming Immuno-Redox Microenvironment in Rheumatoid ArthritisSemantic proximity
Glucose oxidase virus-based nanoreactors for smart breast cancer therapySemantic proximity
Tumor Microenvironment-Responsive CA@ZIF-8/MnO 2 Nanoreactor for Self-Reinforcing Cascade Chemodynamic Therapy and ImmunomodulationSemantic proximity
Nanozyme-Based Supramolecular Self-Assembly As an Artificial Host Defense System For Treatment of Bacterial Infections.Semantic proximity
Modulating macrophage phenotype for accelerated wound healing with chlorogenic acid-loaded nanocomposite hydrogel.Semantic proximity
Select a neighboring publication to make it the new centre.