Article

Sublethal Disulfide Stress Facilitates TLR2-Dependent NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Cells

2026-01-23

Abstract excerpt

<title>Abstract</title> <p>Inflammasomes are innate immune signaling platforms that activate caspase-1, which in turn cleaves gasdermin D (GSDMD) into its mature form, leading to pyroptosis, an inflammatory form of regulated necrosis. It has been reported that bacterial lipopeptides (BLPs) trigger pyroptosis through NLRP7 inflammasome activation. However, the underlying recognition mechanism remains entirely uncl...

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Literature Corpus work: 19231786-25a3-558e-8b38-68667923d195
DOI: 10.21203/rs.3.rs-8485758/v1

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