Article

A systems approach to B-cell development identifies BDNF as a regulator of human B lymphopoiesis

2025-09-04

Abstract excerpt

B-cell aplasia is a major consequence of aging, chemotherapy, and B-cell-depleting immunotherapies, compromising immune protection against infections, cancer, and vaccines. Yet, unlike the myeloid and erythroid lineages, no strategy exists to accelerate human B-cell reconstitution. Here, we used an integrative systems biology approach to identify regulators of human B lymphopoiesis in the bone marrow (BM) microenv...

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Literature Corpus work: 9578efbc-ff3e-51a2-b89d-3d8878d8c931
DOI: 10.1101/2025.08.29.673055

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