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An in vitro model of human hematopoiesis identifies a regulatory role for the aryl hydrocarbon receptor

21 Jul 2023

Abstract excerpt

In vitro models to study simultaneous development of different human immune cells and hematopoietic lineages are lacking. We identified and characterized, using single-cell methods, an in vitro stromal cell-free culture system of human hematopoietic stem and progenitor cell (HSPC) differentiation that allows concurrent development of multiple immune cell lineages. The aryl hydrocarbon receptor (AHR) is a...

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PMID: 37477592
DOI: 10.1182/bloodadvances.2023010169

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