Article

Canonical Analysis of Fluorescent Timer-Anchored Transcriptomes Resolves Joint Temporal and Developmental Progression

2026-03-18

Abstract excerpt

Cell-state transitions during development are shaped by multiple concurrent processes, yet single-cell transcriptomic analyses often rely on static molecular profiles or infer time without an experimental anchor. We developed mCanonicalTockySeq, a systems- level framework that reconstructs temporally resolved developmental state spaces by combining signalling history with single-cell RNA sequencing. Using the Nr4a...

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Literature Corpus work: 9570798b-77c1-528d-a26c-6dfb8ab326f2
DOI: 10.64898/2026.03.16.711988

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