Article

PASTRI: Resolving Stage-Specific Cell-State Dynamics from Annotated Cell Lineage Trees

2026-08-20

Abstract excerpt

Cellular transitions between phenotypic states are fundamental to development and disease, yet quantitative analysis of their dynamics remains challenging. Here we present PASTRI ( P hylogenetic A djacency-based S tate T ransition R ate I nference), a computational framework that infers transition rates from cell lineages/phylogenies annotated with terminal phenotypic states, such as single-cell transcriptom...

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Literature Corpus work: d03d459b-da8e-518b-b265-f0397d038c73
DOI: 10.64898/2026.08.16.745065

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