Article

A cell atlas of human thymic development defines T cell repertoire formation

2020-01-28

Abstract excerpt

The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We utilised single-cell RNA-sequencing (scRNA-seq) to create a cell census of the human thymus and to reconstruct T-cell differentiation trajectories and T-cell receptor (TCR) recombination kinetics. Using this approach, we identified and located...

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Literature Corpus work: 7d931782-caeb-5775-ab2a-253f5e01deaf
DOI: 10.1101/2020.01.28.911115

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