Article

A specific non-bisphosphonate inhibitor of the bifunctional farnesyl/geranylgeranyl diphosphate synthase in malaria parasites

2017-05-04

Abstract excerpt

<h4>Summary</h4> Isoprenoid biosynthesis is essential for Plasmodium falciparum (malaria) parasites and contains multiple validated antimalarial drug targets, including a bifunctional farnesyl and geranylgeranyl diphosphate synthase (FPPS/GGPPS). We identified MMV019313 as an inhibitor of Pf FPPS/GGPPS. Though Pf FPPS/GGPPS is also inhibited by a class of bisphosphonate drugs, MMV019313 has significant advanta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9542c9aa-f4df-58f4-9aa9-01ffee1dbefe
DOI: 10.1101/134338

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A specific non-bisphosphonate inhibitor of the bifunctional farnesyl/geranylgeranyl diphosphate synthase in malaria parasitesDOI 10.1101/134338Read

Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from FosmidomycinSemantic proximity Read

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance.Semantic proximity Read

A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria.Semantic proximity Read

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in <i>P. falciparum</i> MalariaSemantic proximity Read

The heptaprenyl diphosphate synthase (Coq1) is the target of a lipophilic bisphosphonate that protects mice against <i>Toxoplasma gondii</i> infectionSemantic proximity Read

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparumSemantic proximity Read

Driving antimalarial design through understanding of target mechanism.Semantic proximity Read

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.Semantic proximity Read

The MEP Pathway: A New Target for the Development of Herbicides, Antibiotics and Antimalarial DrugsSemantic proximity Read

Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum.Semantic proximity Read

A fast-acting inhibitor of blood-stage <i>P. falciparum</i> with mechanism distinct from artemisinin and chloroquineSemantic proximity Read

Development of Inhibitors of the 2<i>C</i>-Methyl-<scp>d</scp>-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective AgentsSemantic proximity Read