Back to search

Article

The heptaprenyl diphosphate synthase (Coq1) is the target of a lipophilic bisphosphonate that protects mice against <i>Toxoplasma gondii</i> infection

2022-04-04

Abstract excerpt

Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in e.g. sterol biosynthesis and protein prenylation, as well as longer “polyprenyl” diphosphates, used in ubiquinone and menaquinone biosynthesis. Quinones play an essential role in electron transport and are associated with the inner mito...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ef6e779e-0b80-5151-8d1c-6a3c93d3fbb3
DOI
10.1101/2022.04.04.487054
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The heptaprenyl diphosphate synthase (Coq1) is the target of a lipophilic bisphosphonate that protects mice against <i>Toxoplasma gondii</i> infectionDOI 10.1101/2022.04.04.487054
The N-terminus and the chain-length determination domain play a role in the length of the isoprenoid product of the bifunctional Toxoplasma gondii farnesyl diphosphate synthase.Semantic proximity
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparumSemantic proximity
Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from FosmidomycinSemantic proximity
A specific non-bisphosphonate inhibitor of the bifunctional farnesyl/geranylgeranyl diphosphate synthase in malaria parasitesSemantic proximity
CaaX-like protease of cyanobacterial origin is required for complex plastid biogenesis in malaria parasitesSemantic proximity
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infectionsSemantic proximity
Maintenance of pyrophosphate homeostasis in multiple subcellular compartments is essential in <i>Plasmodium falciparum</i>Semantic proximity
Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in <i>Toxoplasma gondii</i>Semantic proximity
Genetic analysis of pyrimidine biosynthetic enzymes in <i>Plasmodium falciparum</i>Semantic proximity
Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of ToxoplasmaSemantic proximity
<i>Toxoplasma gondii</i> requires its plant-like heme biosynthesis pathway for infectionSemantic proximity
Fission yeast decaprenyl diphosphate synthase consists of Dps1 and the newly characterized Dlp1 protein in a novel heterotetrameric structure.Semantic proximity
Select a neighboring publication to make it the new centre.