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Article

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance.

The Journal of biological chemistry - 28 Sept 2018

Yogavel Manickam, Nettleship Joanne E, Sharma Akansha, Harlos Karl, Jamwal Abhishek, Chaturvedi Rini, Sharma Manmohan, Jain Vitul, Chhibber-Goel Jyoti, Sharma Amit

Abstract excerpt

The genomes of the malaria-causing Plasmodium parasites encode a protein fused of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) domains that catalyze sequential reactions in the folate biosynthetic pathway. Whereas higher organisms derive folate from their diet and lack the enzymes for its synthesis, most eubacteria and a number of lower eukaryotes including...

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Identifiers

PMID: 30104413
DOI: 10.1074/jbc.RA118.004558
PMCID: PMC6166723

Genes

DHPS

Variants

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