Article
Mechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum.
Nature communications - 6 Mar 2026
Sanchez Cecilia P, Duffey Maëlle, Celada Romina V, Kucharski Michal, Hoarau Marie, Saeyang Thanaya, Kamchonwongpaisan Sumalee, Sohraby Farzin, de Buhr Svenja, Nunes Alves Ariane, Lucky Amuza Byaruhanga, Miao Jun, Regnault Clement, Dziekan Jerzy M, Bozdech Zbynek, Barrett Michael P, Lanzer Michael
Abstract excerpt
The emergence of multi-drug resistant Plasmodium falciparum underscores the urgent need for new antimalarial therapies. SC83288, a chemically distinct antimalarial compound, is highly effective against P. falciparum both in vivo and in vitro, including strains resistant to artemisinin and partner drugs. Here, we show that SC83288 disrupts blood-stage development by blocking DNA replication and arresting...
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