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The MEP Pathway: A New Target for the Development of Herbicides, Antibiotics and Antimalarial Drugs

1 Jul 2004

Abstract excerpt

Isoprenoids, a diverse group of compounds derived from the five-carbon building units isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), are essential for survival in all organisms. Animals synthesize their isoprenoids from mevalonic acid (MVA), whereas most pathogenic bacteria and the malaria parasites utilize a completely different pathway for IPP and DMAPP synthesis, the...

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PMID: 15279616
DOI: 10.2174/1381612043384006

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