Article

Host-Derived Geranylgeraniol Shields Intraerythrocytic Stages of Malaria Parasites from Fosmidomycin

2025-06-05

Abstract excerpt

<title>Abstract</title> <p>Fosmidomycin was proposed as an antimalarial drug but failed in clinical trials due to recrudescence, a phenomenon whose causes remain poorly understood. The mechanism of action of fosmidomycin is the inhibition of the methylerythritol 4-phosphate (MEP) pathway, essential for producing isoprenoids in <italic>Plasmodium</italic> parasites. The key isoprenoids produced by the MEP pathway...

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Literature Corpus work: 17f5c0ce-240f-5d62-880c-8acacdec4318
DOI: 10.21203/rs.3.rs-6574048/v1

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