Article

Extensive Chromatin Structure-Function Association Revealed by Accurate Compartmentalization Characterization

2021-09-20

Abstract excerpt

Chromosome conformation capture-based experiments have shown that eukaryotic chromosomes are partitioned into A and B compartments conventionally identified by the first eigenvector (EV1) of dimension reduction methods. However, many genomic regions show marginal EV1 values, indicating the ambiguity of A/B compartment scheme on these regions. We develop MOSAIC (MOdularity and Singular vAlue decomposition-based Ide...

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Literature Corpus work: 9a036e69-e923-5e79-a6e5-936434c7a01f
DOI: 10.1101/2021.09.17.460762

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