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Endocytic motif on HIV-1 Env regulates cleavage status and antibody neutralization of cell-free and cell-to-cell infection

2025-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Antibodies inhibit human immunodeficiency virus type 1 (HIV-1) infection by targeting the envelope glycoprotein (Env). Env cleavage is a key determinant of antibody binding, as cleavage reduces Env flexibility and alters glycosylation. Given the greater abundance of uncleaved Env on the cell surface compared to virions, we investigated whether Env endocytosis, initiated through a membrane-proxim...

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Literature Corpus work
952fe389-09aa-5806-ab7b-0536b1175631
DOI
10.1101/2025.09.15.676328
Open publication

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Endocytic motif on HIV-1 Env regulates cleavage status and antibody neutralization of cell-free and cell-to-cell infectionDOI 10.1101/2025.09.15.676328
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