Article

Asymmetric structures and conformational plasticity of the uncleaved full-length human immunodeficiency virus (HIV-1) envelope glycoprotein trimer

2021-03-29

Abstract excerpt

<h4>ABSTRACT</h4> The functional human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer [(gp120/gp41) 3 ] is produced by cleavage of a conformationally flexible gp160 precursor. Gp160 cleavage or the binding of BMS-806, an entry inhibitor, stabilizes the pre-triggered, “closed” (State-1) conformation recognized by rarely elicited broadly neutralizing antibodies. Poorly neutralizing antibodies (p...

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Literature Corpus work: 29ba1147-273d-5f8e-9a75-bdbdd73de0c0
DOI: 10.1101/2021.03.28.437443

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