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Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles

2022-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Human immunodeficiency virus (HIV-1) entry into cells involves triggering of the viral envelope glycoprotein (Env) trimer ((gp120/gp41) 3 ) by the primary receptor, CD4, and coreceptors, CCR5 or CXCR4. The pretriggered (State-1) conformation of the mature (cleaved) Env is targeted by broadly neutralizing antibodies (bNAbs), which are inefficiently elicited compared with poorly neutralizing anti...

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Literature Corpus work
c0abfb16-9148-59e9-ac54-1a3c72688a09
DOI
10.1101/2022.12.01.518799
Open publication

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