Article
Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations.
PLoS pathogens - 1 Jan 2018
Upadhyay Chitra, Feyznezhad Roya, Yang Weiming, Zhang Hui, Zolla-Pazner Susan, Hioe Catarina E
Abstract excerpt
HIV-1 envelope glycoprotein (Env) mediates virus attachment and entry into the host cells. Like other membrane-bound and secreted proteins, HIV-1 Env contains at its N terminus a signal peptide (SP) that directs the nascent Env to the endoplasmic reticulum (ER) where Env synthesis and post-translational modifications take place. SP is cleaved during Env biosynthesis but potentially influences the phenotypic...
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