Article

Inhibition of human immunodeficiency virus (HIV-1) infectivity by expression of poorly or broadly neutralizing antibodies against Env in virus-producing cells

2023-09-09

Abstract excerpt

<h4>ABSTRACT</h4> The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) precursor (gp160) trimerizes, is modified by high-mannose glycans in the endoplasmic reticulum, and is transported via Golgi and non-Golgi secretory pathways to the infected cell surface. In the Golgi, gp160 is partially modified by complex carbohydrates and proteolytically cleaved to produce the mature functional Env trimer, w...

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Literature Corpus work: 2da7c94a-435e-5918-adc6-219303c095e9
DOI: 10.1101/2023.09.08.556927

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