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Combined <i>MYC</i> Activation and <i>Pten</i> Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer

10 Nov 2015

Abstract excerpt

Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations (CNA) are found in most aggressive primary human prostate cancers, and the overall number of such changes is increased in metastases. Chromosome 10q23 deletions, encompassing PTEN, and amplification of 8q24, harboring MYC, are frequently observed, and...

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PMID: 26554830
DOI: 10.1158/0008-5472.can-14-3280

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