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Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers

2020-02-12

Abstract excerpt

In vivo nanocarrier-associated toxicity is a significant and poorly understood hurdle to clinical translation of siRNA nanomedicines. In this work, we demonstrate that platelet activating factor (PAF), an inflammatory lipid mediator, plays a key role in nanocarrier-associated toxicities, and that prophylactic inhibition of the PAF receptor (PAFR) completely prevents these toxicities. High-dose intravenous injectio...

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Literature Corpus work
94f63901-74a2-5a5e-9c1b-7593104b6f5a
DOI
10.1101/2020.02.11.944504
Open publication

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Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid NanocarriersDOI 10.1101/2020.02.11.944504
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