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Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics

28 May 2015

Abstract excerpt

INTRODUCTION: Nucleic acid-based therapeutics (NATs) are proven agents in correcting disorders caused by gene mutations, as treatments against cancer, microbes and viruses, and as vaccine adjuvants. Although many traditional small molecule NATs have been approved for clinical use, commercialization of macromolecular NATs has been considerably slower, and only a few have successfully reached the market....

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PMID: 26017628
DOI: 10.1517/14712598.2015.1014794

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