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Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

18 Aug 2020

Abstract excerpt

Tregs are crucial for maintaining maternal immunotolerance against the semiallogeneic fetus. We investigated the elusive transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during pregnancy. Uterine biopsies, from placental bed (materno-fetal interface) and incision site (control) and blood were obtained from women with uncomplicated pregnancies undergoing cesarean section. Tregs and...

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PMID: 32809975
DOI: 10.1172/jci.insight.137926

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