Article

Human regulatory T cells at the maternal-fetal interface show functional site-specific adaptation with tumor-infiltrating-like features

2019-11-05

Abstract excerpt

<h4>Objectives</h4> Regulatory T cells (Tregs) are crucial for maintaining immune tolerance against the semi-allogeneic fetus during pregnancy. Since their functional profile at the human maternal-fetal interface is still elusive, we investigated the transcriptional profile and functional adaptation of human uterine Tregs (uTregs) during pregnancy. <h4>Methods</h4> Blood and uterine biopsies from the placental b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70f61ec0-9b7a-513f-8729-12eca359e7bf
DOI: 10.1101/820753

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human regulatory T cells at the maternal-fetal interface show functional site-specific adaptation with tumor-infiltrating-like featuresDOI 10.1101/820753Read

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor TregsSemantic proximity Read

Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal InterfaceSemantic proximity Read

Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood.Semantic proximity Read

Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsiaSemantic proximity Read

Regulatory T Cells: New Keys for Further Unlocking the Enigma of Fetal Tolerance and Pregnancy ComplicationsSemantic proximity Read

Resolving ScRNA-Seq Signatures of Antigen-Specific CD4 <sup>+</sup> T Cells in Tolerance across Semi-Allogeneic Transplantation and PregnancySemantic proximity Read

Single-cell transcriptomics reveals markers of regulatory T cell dysfunction in Gestational Diabetes MellitusSemantic proximity Read

Delineating phenotypic heterogeneity in human regulatory T cells across developmental stages and therapeutic sources.Semantic proximity Read

Single-Cell Immune Landscape of Human Recurrent MiscarriageSemantic proximity Read

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscapeSemantic proximity Read

The Immune Atlas of Human Deciduas With Unexplained Recurrent Pregnancy LossSemantic proximity Read

Regulatory T-Cells in Pregnancy: Historical Perspective, State of the Art, and Burning QuestionsSemantic proximity Read