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Deep sequencing of the T cell Receptor reveals common and reproducible CD8 <sup>+</sup> signatures of response to checkpoint immunotherapy

2023-02-12

Abstract excerpt

Immune checkpoint blockade (ICB) has markedly improved outcomes across a range of tumours, including metastatic melanoma (MM). However, peripheral biomarkers of response remain lacking and underlying mechanisms of action incompletely described. A number of studies have demonstrated the value of T cell receptor (TCR) repertoire analysis in determining associations with response, however identifying key groups of T...

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Literature Corpus work
94e345f0-de27-5fac-b0ca-323ce616535d
DOI
10.1101/2023.02.11.528080
Open publication

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Deep sequencing of the T cell Receptor reveals common and reproducible CD8 <sup>+</sup> signatures of response to checkpoint immunotherapyDOI 10.1101/2023.02.11.528080
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