Article
Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma.
Cell reports. Medicine - 17 Nov 2020
Anagnostou Valsamo, Bruhm Daniel C, Niknafs Noushin, White James R, Shao Xiaoshan M, Sidhom John William, Stein Julie, Tsai Hua-Ling, Wang Hao, Belcaid Zineb, Murray Joseph, Balan Archana, Ferreira Leonardo, Ross-Macdonald Petra, Wind-Rotolo Megan, Baras Alexander S, Taube Janis, Karchin Rachel, Scharpf Robert B, Grasso Catherine, Ribas Antoni, Pardoll Drew M, Topalian Suzanne L, Velculescu Victor E
Abstract excerpt
In this study, we incorporate analyses of genome-wide sequence and structural alterations with pre- and on-therapy transcriptomic and T cell repertoire features in immunotherapy-naive melanoma patients treated with immune checkpoint blockade. Although tumor mutation burden is associated with improved treatment response, the mutation frequency in expressed genes is superior in predicting outcome. Increased T cell...
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