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Article

Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1.

Cell reports. Medicine - 17 Nov 2020

Poran Asaf, Scherer Julian, Bushway Meghan E, Besada Rana, Balogh Kristen N, Wanamaker Amy, Williams Reid G, Prabhakara Jasmina, Ott Patrick A, Hu-Lieskovan Siwen, Khondker Zakaria S, Gaynor Richard B, Rooney Michael S, Srinivasan Lakshmi

Abstract excerpt

T cells use highly diverse receptors (TCRs) to identify tumor cells presenting neoantigens arising from genetic mutations and establish anti-tumor activity. Immunotherapy harnessing neoantigen-specific T cells to target tumors has emerged as a promising clinical approach. To assess whether a comprehensive peripheral mononuclear blood cell analysis predicts responses to a personalized neoantigen cancer vaccine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33294862
DOI: 10.1016/j.xcrm.2020.100141
PMCID: PMC7691446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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