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Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells

21 Dec 2016

Abstract excerpt

Heterogeneity of tumor cells and their microenvironment can affect outcome in cancer. Blockade of immune checkpoints (ICPs) expressed only on a subset of immune cells leads to durable responses in advanced melanoma. Tissue-resident memory T (T RM ) cells have recently emerged as a distinct subset of memory T cells in nonlymphoid tissues. Here, we show that functional properties and expression of ICPs within...

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PMID: 28018970
DOI: 10.1172/jci.insight.88955

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