Article

Checkpoint-blocker induced autoimmunity is associated with pretreatment T cell expression profiles and favourable outcome in melanoma

2020-06-24

Abstract excerpt

1 1.1 <h4>Background</h4> Immune checkpoint blockers (ICBs) activate CD8 + T cells to elicit anti-cancer activity but frequently lead to immune-related adverse events (irAEs). The relationship of irAE with baseline parameters and clinical outcome is unclear. We investigated associations between irAE development, CD8 + T cell receptor diversity and expression and clinical outcome in a non-trial setting. 1.2 <h4>Met...

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Literature Corpus work: 1c68004b-2a07-53f4-9076-79d9ed3869cc
DOI: 10.1101/2020.06.23.20138594

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