Article

Defining the genetic determinants of CD8 <sup>+</sup> T cell receptor repertoire in the context of immune checkpoint blockade

2024-11-06

Abstract excerpt

CD8 + T cells play a central role in the cancer response to immune checkpoint blockade (ICB) treatment, with activity predicated upon antigen recognition by the associated T cell receptor (TCR) repertoire. The contribution of genetic variation to this in cancer treatment is under-explored. We have conducted a genome-wide and human leukocyte antigen (HLA)-focused analysis of CD8 + T cell TCR repertoire to identif...

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Literature Corpus work: 73a5f6ea-edcc-5fe3-b4c9-d26b9b50bae3
DOI: 10.1101/2024.11.04.618564

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