Article

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease

2025-02-19

Abstract excerpt

Mitochondrial dynamics, governed by fusion and fission, are crucial for maintaining cellular homeostasis, energy production, and stress adaptation. MFN2 and OPA1, key regulators of mitochondrial fusion, play essential roles beyond their structural functions, influencing bioenergetics, intracellular signalling, and quality control mechanisms such as mitophagy. Disruptions in these processes, often caused by MFN2 or...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94d392eb-c717-5660-92f3-ed48019fdadf
DOI: 10.20944/preprints202502.1547.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and DiseaseDOI 10.20944/preprints202502.1547.v1Read

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease.Semantic proximity Read

Mitochondrial dynamics and disease, OPA1.Semantic proximity Read

Physiological functions of mitochondrial fusion.Semantic proximity Read

Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulationSemantic proximity Read

Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation.Semantic proximity Read

Emerging functions of mammalian mitochondrial fusion and fission.Semantic proximity Read

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases.Semantic proximity Read

Mitofusin 2 Dysfunction and Disease in Mice and MenSemantic proximity Read

Mitochondrial fission in apoptosis, neurodegeneration and aging.Semantic proximity Read

Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts.Semantic proximity Read

Abnormalities of Mitochondrial Dynamics in Neurodegenerative DiseasesSemantic proximity Read

[Mitochondrial morphology and dynamics: actors, mechanisms and functions].Semantic proximity Read