Article

Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation

2025-04-04

Abstract excerpt

Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A patients...

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Literature Corpus work: 7a072b9e-db40-57fd-9205-c2b59fc5ac84
DOI: 10.1101/2025.04.03.647131

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