Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease.

Biomolecules - 18 Mar 2025

Zanfardino Paola, Amati Alessandro, Perrone Mirko, Petruzzella Vittoria

Abstract excerpt

Mitochondrial dynamics, governed by fusion and fission, are crucial for maintaining cellular homeostasis, energy production, and stress adaptation. MFN2 and OPA1, key regulators of mitochondrial fusion, play essential roles beyond their structural functions, influencing bioenergetics, intracellular signaling, and quality control mechanisms such as mitophagy. Disruptions in these processes, often caused by MFN2 or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Charcot-Marie-Tooth Disease
Share to GTP Phosphohydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to Mitochondria

Share to Mitochondrial Dynamics

Share to Mitochondrial Proteins

Share to Optic Atrophy, Autosomal Dominant

Source

Open in PubMed Open full text

Identifiers

PMID: 40149969
DOI: 10.3390/biom15030433
PMCID: PMC11940761

Genes

MFN2
OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease.PMID 40149969Read ↗

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and DiseaseSemantic proximity Read ↗

Mitochondrial dynamics and disease, OPA1.Semantic proximity Read ↗

Physiological functions of mitochondrial fusion.Semantic proximity Read ↗

Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation.Semantic proximity Read ↗

Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulationSemantic proximity Read ↗

Emerging functions of mammalian mitochondrial fusion and fission.Semantic proximity Read ↗

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases.Semantic proximity Read ↗

Mitochondrial fission in apoptosis, neurodegeneration and aging.Semantic proximity Read ↗

Mitofusin 2 mutation drives cell proliferation in Charcot-Marie-Tooth 2A fibroblasts.Semantic proximity Read ↗

Abnormalities of Mitochondrial Dynamics in Neurodegenerative DiseasesSemantic proximity Read ↗

Mitofusin 2 Dysfunction and Disease in Mice and MenSemantic proximity Read ↗

[Mitochondrial morphology and dynamics: actors, mechanisms and functions].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.