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Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation.

Cell death & disease - 5 Jun 2026

Lagos Daniel, de Santiago Pamela R, Pérez-Bravo Nicolás, Cartes-Saavedra Benjamín, Vial-Brizzi Josefa, Troncoso-Chandía Diego, Podmanicky Oliver, Horvath Rita, Eisner Verónica

Abstract excerpt

Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2 A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A...

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Identifiers

PMID: 42248856
DOI: 10.1038/s41419-026-08838-3
PMCID: PMC13458151

Genes

MFN2
MFN1
OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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