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Article

Adaptive Gene Amplification As an Intermediate Step in the Expansion of Virus Host Range

13 Mar 2014

Abstract excerpt

The majority of recently emerging infectious diseases in humans is due to cross-species pathogen transmissions from animals. To establish a productive infection in new host species, viruses must overcome barriers to replication mediated by diverse and rapidly evolving host restriction factors such as protein kinase R (PKR). Many viral antagonists of these restriction factors are species specific. For example, the...

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PMID: 24626510
DOI: 10.1371/journal.ppat.1004002

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