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Article

Metabolic Vulnerabilities and Epigenetic Dysregulation in Myeloproliferative Neoplasms.

Frontiers in immunology - 1 Jan 2020

Sharma Vasundhara, Wright Kenneth L, Epling-Burnette Pearlie K, Reuther Gary W

Abstract excerpt

The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are associated with clonal myelopoiesis, elevated risk of death due to thrombotic complications, and transformation to acute myeloid leukemia (AML). JAK2 inhibitors improve the quality of life for MPN patients, but these approved therapeutics do not readily reduce the natural course of disease or antagonize the neoplastic clone. An understanding...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33329600
DOI: 10.3389/fimmu.2020.604142
PMCID: PMC7734315

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