Article

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia.

2021-05-20

Abstract excerpt

<title>Abstract</title> <p>Typified by oxidative phosphorylation (OXPHOS), mitochondria catalyze a wide variety of cellular processes seemingly critical for malignant growth. As such, there is considerable interest in targeting mitochondrial metabolism in cancer. However, notwithstanding the few drugs targeting mutant dehydrogenase activity, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous fro...

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Literature Corpus work: 78d6b51a-2a4f-52aa-8844-c330011575a4
DOI: 10.21203/rs.3.rs-64203/v2

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