Article
Somatic mtDNA mutation burden shapes metabolic plasticity in leukemogenesis.
Science advances - 3 Jan 2025
Li-Harms Xiujie, Lu Jingjun, Fukuda Yu, Lynch John, Sheth Aditya, Pareek Gautam, Kaminski Marcin M, Ross Hailey S, Wright Christopher W, Smith Amber L, Wu Huiyun, Wang Yong-Dong, Valentine Marc, Neale Geoffrey, Vogel Peter, Pounds Stanley, Schuetz John D, Ni Min, Kundu Mondira
Abstract excerpt
The role of somatic mitochondrial DNA (mtDNA) mutations in leukemogenesis remains poorly characterized. To determine the impact of somatic mtDNA mutations on this process, we assessed the leukemogenic potential of hematopoietic progenitor cells (HPCs) from mtDNA mutator mice (Polg D257A) with or without NMyc overexpression. We observed a higher incidence of spontaneous leukemogenesis in recipients transplanted...
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