Article

Hypoxia-mediated regulation of mitochondrial transcription factors: Implications for hypertensive renal physiology

2019-10-24

Abstract excerpt

Kidneys have a high resting metabolic rate and low tissue partial pressure of oxygen due to enhanced mitochondrial oxygen consumption and ATP production for active solute transport. Enhanced mitochondrial activity leads to progressive hypoxia from the renal cortex to renal medulla. Renal tubulointerstitial hypoxia (TiH) is severe in hypertensive rats due to increased sodium reabsorption within their nephrons. Addi...

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Literature Corpus work: 947d10c6-f4ad-51f1-8beb-e0c10a052c7a
DOI: 10.1101/816470

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