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Article

The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia.

The Journal of biological chemistry - 10 Oct 2003

Leonard Martin O, Cottell David C, Godson Catherine, Brady Hugh R, Taylor Cormac T

Abstract excerpt

Epithelial cells of the kidney represent a primary target for hypoxic injury in ischemic acute renal failure (ARF); however, the underlying transcriptional mechanism(s) remain undefined. In this study, human proximal tubular epithelial cells (HK-2) exposed to hypoxia in vitro demonstrated a non-lethal but dysfunctional phenotype, closely reflective of the epithelial pathobiology of ARF. HK-2 cells exposed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12885785
DOI: 10.1074/jbc.M302560200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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