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Article

IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1α

23 Jul 2011

Abstract excerpt

Increased expression of Induced-by-High-Glucose 1 (IHG-1) associates with tubulointerstitial fibrosis in diabetic nephropathy. IHG-1 amplifies TGF-β1 signaling, but the functions of this highly-conserved protein are not well understood. IHG-1 contains a putative mitochondrial-localization domain, and here we report that IHG-1 is specifically localized to mitochondria. IHG-1 overexpression increased mitochondrial...

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PMID: 21784897
DOI: 10.1681/asn.2010111154

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