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Article

Transcriptomic changes in human renal proximal tubular cells revealed under hypoxic conditions by RNA sequencing.

International journal of molecular medicine - 1 Sept 2016

Yu Wenmin, Li Yiping, Wang Zhi, Liu Lei, Liu Jing, Ding Fengan, Zhang Xiaoyi, Cheng Zhengyuan, Chen Pingsheng, Dou Jun

Abstract excerpt

Chronic hypoxia often occurs among patients with chronic kidney disease (CKD). Renal proximal tubular cells may be the primary target of a hypoxic insult. However, the underlying transcriptional mechanisms remain undefined. In this study, we revealed the global changes in gene expression in HK‑2 human renal proximal tubular cells under hypoxic and normoxic conditions. We analyzed the transcriptome of HK‑2 cells...

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Source

Identifiers

PMID: 27432315
DOI: 10.3892/ijmm.2016.2677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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