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Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts

11 Aug 2017

Abstract excerpt

Accumulating evidence suggests that dysregulation of hypoxia-regulated transcriptional mechanisms is involved in development of chronic kidney diseases (CKD). However, it remains unclear how hypoxia-induced transcription factors (HIFs) and subsequent biological processes contribute to CKD development and progression. In our study, genome-wide expression profiles of more than 200 renal biopsies from patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28819298
DOI: 10.1038/s41598-017-08492-y

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