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Article

Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease

30 Apr 2017

Abstract excerpt

The pathogenesis of chronic kidney disease (CKD) is complex and apparently multifactorial. Hypoxia or decrease in oxygen supply in kidney tissues has been implicated in CKD. Hypoxia inducible factors (HIF) are a small family of transcription factors that are mainly responsive to hypoxia and mediate hypoxic response. HIF plays a critical role in renal fibrosis during CKD through the modulation of gene...

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PMID: 28468297
DOI: 10.3390/ijms18050950

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