Article

A molecule-inhibitor of the integrated stress response regulates activity of mammalian eukaryotic translation initiation factor 2B

2018-01-01

Abstract excerpt

The Integrated Stress Response (ISR) is a conserved eukaryotic translational and transcriptional program implicated in mammalian metabolism, memory and immunity. Although mainly considered to be a protective mechanism, prolonged and severe ISR can result in cell death. The ISR is activated by diverse stress pathways converged on phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eI...

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Identifiers and source

Literature Corpus work: 9474b241-ee60-5bcc-8a9f-6ae0fcaf4414
DOI: 10.17863/cam.31576

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