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Article

Insights into the architecture of the eIF2Bα/β/δ regulatory subcomplex.

Biochemistry - 3 Jun 2014

Bogorad Andrew M, Xia Bing, Sandor Dana G, Mamonov Artem B, Cafarella Tanya R, Jehle Stefan, Vajda Sandor, Kozakov Dima, Marintchev Assen

Abstract excerpt

Eukaryotic translation initiation factor 2B (eIF2B), the guanine nucleotide exchange factor for the G-protein eIF2, is one of the main targets for the regulation of protein synthesis. The eIF2B activity is inhibited in response to a wide range of stress factors and diseases, including viral infections, hypoxia, nutrient starvation, and heme deficiency, collectively known as the integrated stress response. eIF2B...

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Identifiers

PMID: 24811713
DOI: 10.1021/bi500346u
PMCID: PMC4045321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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